Tumores colorrectales
Desarrollo y puesta en marcha de una estrategia de medicina personalizada en pacientes con cáncer colorectal.
Grupo consolidado en el manejo de pacientes con cáncer colorectal que reúne y coordina en un equipo multidisciplinar toda la investigación básica, clínica y traslacional realizada en la Clínica Universidad de Navarra y en el Centro para la Investigación Médica Aplicada (CIMA) en torno al desarrollo e innovación terapeutica en el cáncer de colon.
Fruehbeck, G, Gómez-Ambrosi, J, Ramirez, B, Becerril, S, Rodriguez, A, Mentxaka, A, Valenti, V, Moncada, R, Reina, G, Baixauli, J, Casado, M, Silva, C, Escalada, J, Catalán, V
"Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes".
Cell. Mol. Life Sci.. 81(1): 77. 2024. [doi:10.1007/s00018-024-05124-3]
Aliseda, D, Martí-Cruchaga, P, Zozaya, G, Blanco, N, Ponz, M, Chopitea, A, Rodríguez, J, Castañón, E, Pardo, F, Rotellar, F
"Neoadjuvant therapy versus upfront surgery in resectable pancreatic cancer: reconstructed patient-level meta-analysis of randomized clinical trials".
BJS Open. 8(5): zrae087. 2024. [doi:10.1093/bjsopen/zrae087]
Neira, G, Gómez-Ambrosi, J, Cienfuegos, JA, Ramirez, B, Becerril, S, Rodríguez, A, Burrell, MA, Baixauli, J, Mentxaka, A, Casado, M, Silva, C, Escalada, J, Frühbeck, G, Catalán, V
"Increased expression of IL-1ß in adipose tissue in obesity influences the development of colon cancer by promoting inflammation".
J. Physiol. Biochem.. . 2024. [doi:10.1007/s13105-024-01048-5]
Eguren-Santamaria, I, de Piérola, EF, Camps, G, Martín-Muñoz, P, Campos, M, Cuculescu, D, Aguilera-Buenosvinos, I, López, IR, Salido-Vallejo, R, Alexandru, R, de Andrea, CE, Alvarez-Gigli, L, Berraondo, P, Melero, I, Sanmamed, MF
"MHC class I and II-deficient humanized mice are suitable tools to test the long-term antitumor efficacy of immune checkpoint inhibitors and T-cell engagers".
J. Immunother. Cancer. 12(9): e008516. 2024. [doi:10.1136/jitc-2023-008516]
Atienza, AV, Iriarte, OA, Sarrias, OR, Lizundia, TZ, Beristain, OS, Casajus, AE, Gigli, LA, Sastre, FR, García, IM, Rodríguez, JR
"Neoadjuvant Statistical Algorithm to Predict Individual Risk of Relapse in Patients with Resected Liver Metastases from Colorectal Cancer".
Biomedicines. 12(8): 1859. 2024. [doi:10.3390/biomedicines12081859]
Rubio-Pérez, L, Frago, S, Compte, M, Navarro, R, Harwood, SL, Lázaro-Gorines, R, Gómez-Rosel, M, Hangiu, O, Silva-Pilipich, N, Vanrell, L, Smerdou, C, Alvarez-Vallina, L
"Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity".
Antibodies. 13(2): 34. 2024. [doi:10.3390/antib13020034]
González, A, Fullaondo, A, Rodríguez, J, Tirnauca, C, Odriozola, I, Odriozola, A
"Conjugated linoleic acid metabolite impact in colorectal cancer: a potential microbiome-based precision nutrition approach".
Nutr. Rev.. . 2024. [doi:10.1093/nutrit/nuae046]
Rodríguez-Hernández, MA, Baena-Bustos, M, Carneros, D, Zurita-Palomo, C, Muñoz-Pinillos, P, Millán, J, Padillo, FJ, Smerdou, C, von Kobbe, C, Rose-John, S, Bustos, M
"Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2-infected mice and reduces endotheliopathy".
EBioMedicine. 103: 105132. 2024. [doi:10.1016/j.ebiom.2024.105132]
Arredondo, J, Almeida, A, Castanon, C, Sanchez, C, Villafane, A, Tejedor, P, Simo, V, Baixauli, J, Rodriguez, J, Pastor, C
"The ELECLA trial: A multicentre randomised control trial on outcomes of neoadjuvant treatment on locally advanced colon cancer".
Colorectal Dis.. 26(4): 745 - 753. 2024. [doi:10.1111/codi.16908]
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